Wang Lina, Xu Zhiliang, Khawar Muhammad Babar, Liu Chao, Li Wei
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, People's Republic of China.
Reproduction. 2017 Sep;154(3):R65-R79. doi: 10.1530/REP-17-0153.
Meiosis is a specialized process that produces haploid gametes from diploid cells by a single round of DNA replication followed by two successive cell divisions. It contains many special events, such as programmed DNA double-strand break (DSB) formation, homologous recombination, crossover formation and resolution. These events are associated with dynamically regulated chromosomal structures, the dynamic transcriptional regulation and chromatin remodeling are mainly modulated by histone modifications, termed 'histone codes'. The purpose of this review is to summarize the histone codes that are required for meiosis during spermatogenesis and oogenesis, involving meiosis resumption, meiotic asymmetric division and other cellular processes. We not only systematically review the functional roles of histone codes in meiosis but also discuss future trends and perspectives in this field.
减数分裂是一种特殊的过程，通过一轮DNA复制，随后进行两次连续的细胞分裂，从二倍体细胞产生单倍体配子。它包含许多特殊事件，如程序性DNA双链断裂（DSB）形成、同源重组、交叉形成和解决。这些事件与动态调节的染色体结构相关，动态转录调节和染色质重塑主要由组蛋白修饰调节，称为“组蛋白密码”。本综述的目的是总结精子发生和卵子发生过程中减数分裂所需的组蛋白密码，包括减数分裂恢复、减数分裂不对称分裂和其他细胞过程。我们不仅系统地综述了组蛋白密码在减数分裂中的功能作用，还讨论了该领域的未来趋势和前景。
