Voros Charalampos, Varthaliti Antonia, Mavrogianni Despoina, Athanasiou Diamantis, Athanasiou Antonia, Athanasiou Aikaterini, Papahliou Anthi-Maria, Zografos Constantinos G, Topalis Vasileios, Kondili Panagiota, Darlas Menelaos, Sina Sophia, Daskalaki Maria Anastasia, Theodora Marianna, Antsaklis Panos, Daskalakis Georgios
1st Department of Obstetrics and Gynecology, 'Alexandra' General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece.
IVF Athens Reproduction Center V. Athanasiou, 15123 Maroussi, Greece.
Biomedicines. 2025 Mar 17;13(3):730. doi: 10.3390/biomedicines13030730.
: Epigenetic modifications have an important role in controlling ovarian function, modulating ovarian response and implantation success in Assisted Reproductive Technologies (ART). The alterations, such as DNA methylation and non-coding RNA control, have been identified as key variables regulating ovarian physiology and reproductive outcomes. This systematic review investigates the significance of epigenetic pathways in ovarian function, with an emphasis on their effect on ART success rates. : A thorough search of the PubMed, Scopus, and EMBASE databases was performed to find articles published between 2015 and 2024 that investigated the connection between epigenetic changes and ovarian function in ART patients. Studies that examined miRNA expression, DNA methylation, and histone changes in follicular fluid, granulosa cells, and embryos were included. The study followed the PRISMA recommendations to guarantee scientific rigor and repeatability. The data were combined into a thorough study of epigenetic markers linked to ovarian aging, ovarian reserve, and implantation success. : A total of 15 studies satisfied the inclusion criteria, with substantial relationships found between distinct epigenetic markers and ovarian function. Changes in miRNA expression patterns in follicular fluid and granulosa cells were associated with oocyte maturation, ovarian reserve, and implantation potential. Women with low ovarian reserve and polycystic ovary syndrome (PCOS) have different DNA methylation patterns. MiR-27a-3p and miR-15a-5p were shown to be involved with granulosa cell malfunction and poor ovarian response, whereas global DNA hypomethylation was linked to ovarian aging and ART results. : Epigenetic alterations affect ovarian function via pathways that control hormone signaling, follicular development, and implantation success. Further study is needed to determine the practical applicability of epigenetic biomarkers in predicting ART effectiveness and enhancing patient treatment procedures.
表观遗传修饰在控制卵巢功能、调节卵巢反应以及辅助生殖技术（ART）中的着床成功率方面发挥着重要作用。诸如DNA甲基化和非编码RNA调控等改变已被确定为调节卵巢生理和生殖结局的关键变量。本系统综述探讨了表观遗传途径在卵巢功能中的重要性，重点关注其对ART成功率的影响。：对PubMed、Scopus和EMBASE数据库进行了全面检索，以查找2015年至2024年间发表的研究ART患者表观遗传变化与卵巢功能之间联系的文章。纳入了研究卵泡液、颗粒细胞和胚胎中miRNA表达、DNA甲基化和组蛋白变化的研究。该研究遵循PRISMA建议以确保科学严谨性和可重复性。数据被整合为对与卵巢衰老、卵巢储备和着床成功相关的表观遗传标记的全面研究。：共有15项研究符合纳入标准，发现不同的表观遗传标记与卵巢功能之间存在显著关联。卵泡液和颗粒细胞中miRNA表达模式的变化与卵母细胞成熟、卵巢储备和着床潜力相关。卵巢储备低和多囊卵巢综合征（PCOS）的女性具有不同的DNA甲基化模式。MiR-27a-3p和miR-15a-5p被证明与颗粒细胞功能障碍和卵巢反应不良有关，而整体DNA低甲基化与卵巢衰老和ART结果相关。：表观遗传改变通过控制激素信号传导、卵泡发育和着床成功的途径影响卵巢功能。需要进一步研究以确定表观遗传生物标志物在预测ART有效性和改进患者治疗程序方面的实际适用性。
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