McGill Group for Suicide Studies, McGill University, Douglas Mental Health University Institute, Montreal, QC, Canada.
Department of Psychiatry, McGill University, Douglas Mental Health University Institute, Montreal, QC, Canada.
Mol Psychiatry. 2017 Oct;22(10):1395-1412. doi: 10.1038/mp.2017.141. Epub 2017 Jul 11.
Suicide is a major public health concern and a leading cause of death in most societies. Suicidal behaviour is complex and heterogeneous, likely resulting from several causes. It associates with multiple factors, including psychopathology, personality traits, early-life adversity and stressful life events, among others. Over the past decades, studies in fields ranging from neuroanatomy, genetics and molecular psychiatry have led to a model whereby behavioural dysregulation, including suicidal behaviour (SB), develops as a function of biological adaptations in key brain systems. More recently, the unravelling of the unique epigenetic processes that occur in the brain has opened promising avenues in suicide research. The present review explores the various facets of the current knowledge on suicidality and discusses how the rapidly evolving field of neurobehavioural epigenetics may fuel our ability to understand, and potentially prevent, SB.
自杀是一个主要的公共卫生关注点，也是大多数社会中主要的死亡原因之一。自杀行为复杂且具有异质性，可能由多种原因导致。它与多种因素相关，包括精神病理学、人格特质、早期生活逆境和生活应激事件等。在过去的几十年中，神经解剖学、遗传学和分子精神病学等领域的研究提出了一个模型，即行为调节障碍，包括自杀行为（SB），是关键大脑系统中生物适应性的一种功能。最近，对大脑中发生的独特表观遗传过程的揭示为自杀研究开辟了有前途的途径。本综述探讨了当前关于自杀倾向的各个方面，并讨论了神经行为表观遗传学这一快速发展的领域如何增强我们理解和预防 SB 的能力。
