自杀表观遗传学：近期进展综述
Suicide epigenetics, a review of recent progress.
作者信息
Cheung Serina, Woo Julia, Maes Miriam S, Zai Clement C
机构信息
Neurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada.
Neurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Faculty of Medicine, University of Toronto, Canada.
出版信息
J Affect Disord. 2020 Mar 15;265:423-438. doi: 10.1016/j.jad.2020.01.040. Epub 2020 Jan 15.
BACKGROUND
Suicide results in over 800,000 deaths every year, making it a major public health concern worldwide. It is highly complex, with genetic and environmental influences. Epigenetic mechanisms, including DNA methylation, miRNA, and histone modifications, could explain the complex interplay of environmental risk factors with genetic risk factors in the emergence of suicidal behavior.
METHODS
Here, we review the literature on suicide epigenetics over the past 10 years.
RESULTS
There has been significant progress in the field of suicide epigenetics, with emerging findings in the brain-derived neurotrophic factor and hypothalamic-pituitary-adrenal axis genes.
LIMITATIONS
Studying patient subgroups is needed in order to extract more comparable and reproducible epigenetic findings in suicide.
CONCLUSIONS
It is crucial to consider suicidal patients or suicide victims' distal and proximal past history e.g., early-life adversity and psychiatric disorder in epigenetic studies of suicidality.
背景
自杀每年导致超过80万例死亡，使其成为全球主要的公共卫生问题。自杀行为高度复杂，受遗传和环境因素影响。表观遗传机制，包括DNA甲基化、微小RNA（miRNA）和组蛋白修饰，可能解释环境风险因素与遗传风险因素在自杀行为发生过程中的复杂相互作用。
方法
在此，我们回顾了过去10年关于自杀表观遗传学的文献。
结果
自杀表观遗传学领域取得了重大进展，在脑源性神经营养因子和下丘脑-垂体-肾上腺轴基因方面有新的发现。
局限性
为了在自杀研究中提取更具可比性和可重复性的表观遗传学发现，需要对患者亚组进行研究。
结论
在自杀行为的表观遗传学研究中，考虑自杀患者或自杀受害者的远期和近期既往史（如早年逆境和精神疾病）至关重要。
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