Nordmann R
Acta Psychiatr Belg. 1985;85:667-75.
Chronic alcohol intoxication is able to modify the lipid structure and fluidity of synaptosomal membranes and influence hereby the activity of some membraneous enzymes and receptors. These changes could play a key role in the development of alcohol tolerance and dependence. This "membraneous hypothesis" allows to explain, at least in part, the influence of nutritional factors as well as of differences in genetic or individual susceptibility on alcohol dependence. It suggests furthermore the possibility of prevention of alcohol dependence through dietary and pharmacological means.
慢性酒精中毒能够改变突触体膜的脂质结构和流动性，从而影响一些膜酶和受体的活性。这些变化可能在酒精耐受性和依赖性的发展中起关键作用。这种“膜假说”至少可以部分解释营养因素以及遗传或个体易感性差异对酒精依赖的影响。此外，它还提出了通过饮食和药理学手段预防酒精依赖的可能性。
