Voevodsky Institute of Chemical Kinetics and Combustion, 3 Institutskaya Str., 630090, Novosibirsk, Russian Federation.
Nikolaev Institute of Inorganic Chemistry, 3 Lavrentiev Ave., 119333, 630090, Novosibirsk, Russian Federation.
Dalton Trans. 2017 Jul 25;46(29):9440-9450. doi: 10.1039/c7dt01529a.
Diazide diamino complexes of Pt(iv) are considered as prospective prodrugs in oxygen-free photodynamic therapy (PDT). Primary photophysical and photochemical processes for cis,trans,cis-[Pt(N)(OH)(NH)] and trans,trans,trans-[Pt(N)(OH)(NH)] complexes were studied by means of stationary photolysis, nanosecond laser flash photolysis and ultrafast kinetic spectroscopy. The process of photolysis is multistage. The first stage is the photosubstitution of an azide ligand to a water molecule. This process was shown to be a chain reaction involving redox stages. Pt(iv) and Pt(iii) intermediates responsible for the chain propagation were recorded using ultrafast kinetic spectroscopy and nanosecond laser flash photolysis. The mechanism of photosubstitution is proposed.
二氮烯二氨基配合物铂（IV）被认为是在乏氧光动力治疗（PDT）中有前景的前药。通过稳态光解、纳秒激光闪光光解和超快动力学光谱学研究了顺式，反式，顺式-[Pt（N）（OH）（NH）]和反式，反式，反式-[Pt（N）（OH）（NH）]配合物的初始光物理和光化学过程。光解过程是多阶段的。第一阶段是叠氮化物配体向水分子的光取代。该过程被证明是一个涉及氧化还原阶段的链式反应。使用超快动力学光谱学和纳秒激光闪光光解记录了负责链传播的 Pt（IV）和 Pt（III）中间体。提出了光取代的机理。
