Shriner Daniel
Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland.
Curr Protoc Hum Genet. 2017 Jul 11;94:1.23.1-1.23.8. doi: 10.1002/cphg.44.
Admixture mapping is a powerful method of gene mapping for diseases or traits that show differential risk by ancestry. Admixture mapping has been applied most often to Americans who trace ancestry to various combinations of Native Americans, Europeans, and West Africans. Recent developments in admixture mapping include improvements in methods and the reference data needed to make inferences about ancestry, as well as extensions of the mapping approach in the framework of linear mixed models. In this unit, the key concepts of admixture mapping are outlined. Several approaches for inferring local ancestry are described, and strategies for performing admixture mapping depending on the study design are provided. Finally, comparisons and contrasts between linkage analysis, association analysis, and admixture mapping are provided, with an emphasis on integrating admixture mapping and association testing. © 2017 by John Wiley & Sons, Inc.
混合映射是一种用于对因血统而显示出不同风险的疾病或性状进行基因定位的强大方法。混合映射最常用于那些将血统追溯到美洲原住民、欧洲人和西非人的各种组合的美国人。混合映射的最新进展包括方法的改进以及进行血统推断所需的参考数据，以及在线性混合模型框架内对映射方法的扩展。在本单元中，概述了混合映射的关键概念。描述了几种推断局部血统的方法，并提供了根据研究设计进行混合映射的策略。最后，对连锁分析、关联分析和混合映射进行了比较和对比，重点是整合混合映射和关联测试。© 2017约翰威立父子公司版权所有
