Shriner Daniel
Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, USA.
Curr Protoc Hum Genet. 2013;Chapter 1:Unit 1.23. doi: 10.1002/0471142905.hg0123s76.
Admixture mapping is a powerful method of gene mapping for diseases or traits that show differential risk by ancestry. Admixture mapping has been applied most often to African Americans who trace ancestry to Europeans and West Africans. Recent developments in admixture mapping include improvements in methods to take advantage of higher densities of genetic variants, as well as extensions to admixed populations with three or more ancestral populations, such as Latino Americans. In this unit, the author outlines the key concepts of admixture mapping. The author describes several approaches for inferring local ancestry and provides strategies for performing admixture mapping depending on the study design. Finally, the author compares and contrasts linkage analysis, association analysis, and admixture mapping, with an emphasis on integrating admixture mapping and association testing.
混合映射是一种用于对因血统而显示出不同风险的疾病或性状进行基因定位的强大方法。混合映射最常应用于追溯其血统为欧洲人和西非人的非裔美国人。混合映射的最新进展包括改进利用更高密度遗传变异的方法，以及扩展到具有三个或更多祖先群体的混合群体，如拉丁裔美国人。在本单元中，作者概述了混合映射的关键概念。作者描述了几种推断局部血统的方法，并根据研究设计提供了进行混合映射的策略。最后，作者比较并对比了连锁分析、关联分析和混合映射，重点是整合混合映射和关联测试。
