Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, China.
Org Lett. 2017 Jul 21;19(14):3783-3786. doi: 10.1021/acs.orglett.7b01664. Epub 2017 Jul 11.
Pd(II)-catalyzed three-component reactions via trapping of ammonium ylides with N-alkylquinolinium salts are reported. These reactions provided polyfunctional polycyclic tetrahydroquinolines or 4-substituted 1,4-dihydroquinolines in excellent yields (89-99% and 89-98%, respectively) with high regioselectivities and moderate to good diastereoselectivities (up to 95:5 dr) under mild reaction conditions.
Pd(II)催化的三组分反应通过捕获铵叶立德与 N-烷基喹啉鎓盐，提供了多官能团多环四氢喹啉或 4-取代的 1,4-二氢喹啉，产率优异（分别为 89-99%和 89-98%），区域选择性高，非对映选择性适中至良好（最高可达 95:5 dr），反应条件温和。
