交叉复分解方法在三环海洋生物碱 (-)-Fasicularin 和 (-)-Lepadiformine A 中的应用。
Cross-Metathesis Approach to the Tricyclic Marine Alkaloids (-)-Fasicularin and (-)-Lepadiformine A.
机构信息
School of Chemistry, Monash University , Clayton, Victoria 3800, Australia.
出版信息
J Org Chem. 2017 Aug 18;82(16):8497-8505. doi: 10.1021/acs.joc.7b01135. Epub 2017 Aug 8.
PMID:28696718
Abstract
A cross-metathesis protocol has been developed to provide facile access to highly hindered trisubstituted α-branched olefins, which when coupled with a cationic azaspirocyclization reaction, generates the marine alkaloids (-)-fasicularin 2 and a pro-forma synthesis of (-)-lepadiformine A 1.
摘要
已经开发出一种交叉复分解协议，以方便获得高度受阻的三取代α-支化烯烃，当与阳离子氮杂螺环化反应偶联时，生成海洋生物碱(-)-fasicularin 2 和(-)-lepadiformine A 1 的前体合成物。
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