Schleissner Carmen, Cañedo Librada M, Rodríguez Pilar, Crespo Cristina, Zúñiga Paz, Peñalver Ana, de la Calle Fernando, Cuevas Carmen
Research and Development Department, PharmaMar S.A. , Avenida de los Reyes, 1, Colmenar Viejo 28770, Madrid, Spain.
J Nat Prod. 2017 Jul 28;80(7):2170-2173. doi: 10.1021/acs.jnatprod.7b00408. Epub 2017 Jul 11.
The polyketide pederin family are cytotoxic compounds isolated from insects, lichen, and marine sponges. During the past decade, different uncultivable bacteria symbionts have been proposed as the real producers of these compounds, such as those found in insects, lichen, and marine sponges, and their trans-AT polyketide synthase gene clusters have been identified. Herein we report the isolation and biological activities of a new analogue of the pederin family, compound 1, from the culture of a marine heterotrophic alphaproteobacterium, Labrenzia sp. PHM005. This is the first report of the production of a pederin-type compound by a free-living marine bacteria that could be cultured in the laboratory.
聚酮类化合物佩德菌素家族是从昆虫、地衣和海洋海绵中分离出的细胞毒性化合物。在过去十年中，不同的不可培养细菌共生体被认为是这些化合物的真正生产者，比如在昆虫、地衣和海洋海绵中发现的共生体，并且它们的反式-AT聚酮合酶基因簇已被鉴定。在此，我们报告了从海洋异养α-变形菌Labrenzia sp. PHM005的培养物中分离出一种新的佩德菌素家族类似物化合物1及其生物活性。这是关于可在实验室培养的自由生活海洋细菌产生佩德菌素类化合物的首次报道。
