Department of Chemistry and Chemical Biology, Harvard University , Cambridge, Massachusetts 02138, United States.
Org Lett. 2017 Jul 21;19(14):3883-3886. doi: 10.1021/acs.orglett.7b01768. Epub 2017 Jul 11.
The previously unknown 5-spirocyclohexylisoimidazole has been made efficiently and simply by reaction of ammonia, glyoxal hydrate, and cyclohexanone. It is a very useful precursor for the diastereocontrolled synthesis of many C-symmetric 1,2-diamines, a class which is important for the generation of a variety of C-symmetric reagents and catalysts for enantioselective synthesis.
先前未知的 5-螺环环己基异咪唑可通过氨、乙二醛水合物和环己酮的反应高效且简单地制备。它是许多对映选择性控制合成的 C-对称 1,2-二胺的非常有用的前体，这类化合物对于生成各种 C-对称试剂和手性催化剂用于对映选择性合成非常重要。
