Yu Wei, Shi Ruizhi, Li Jim, Lan Yong, Li Qian, Hu Shanlian
a Department of Medical Affairs , Pfizer , Beijing , China.
b Department of Medical Affairs , Pfizer Inc. , San Diego , CA , USA.
Curr Med Res Opin. 2018 Feb;34(2):197-207. doi: 10.1080/03007995.2017.1354833. Epub 2017 Aug 9.
To evaluate the hyperlipidemia prevention programs and policies in different countries and highlight the need of reforming the hyperlipidemia prevention policies in China to lower the growing cardiovascular disease (CVD) risk.
PubMed, Google Scholar and Cochrane were searched for global hyperlipidemia prevention policies. Government-funded policies pertaining to lipid management were considered for this review. Only those studies that evaluated the success of prevention policies on the basis of: (i) achievement of hyperlipidemia targets; (ii) improvement in Cardiovascular (CV) risk reduction; and (iii) outcomes with reduction in hyperlipidemia after implementation of the policy, were included.
Several global policies and programs aimed to improve CV health by highlighting lipid profile management. Implementation of the global and national policies led to improvement in cholesterol related outcomes such as availability of diagnostic measures, awareness of the risk factors, decrease in cholesterol levels, achieving healthy lifestyle to prevent CVD and improvement in availability of hypolipidemic medications, etc. Statins have been covered under reimbursement policies in many countries to improve usage and thereby preventing incidence of stroke and CVD. We observed a need for introducing new programs in China as the ongoing hyperlipidemia management policies are inadequate. The World Bank Report 2016 recommended that prevention policies in China be modeled on the US Million Hearts program.
New hyperlipidemia prevention policies must set a time-bound target, and need to be patient and clinician centric in terms of applications, and revised periodically for long-term benefits.
评估不同国家的高脂血症预防项目和政策,并强调中国改革高脂血症预防政策以降低日益增长的心血管疾病(CVD)风险的必要性。
检索PubMed、谷歌学术和考科蓝数据库以获取全球高脂血症预防政策。本综述考虑了政府资助的与血脂管理相关的政策。仅纳入那些基于以下方面评估预防政策成功与否的研究:(i)高脂血症目标的达成情况;(ii)心血管(CV)风险降低的改善情况;(iii)政策实施后高脂血症降低的结果。
若干全球政策和项目旨在通过突出血脂管理来改善心血管健康。全球和国家政策的实施带来了与胆固醇相关的结果改善,如诊断措施的可及性、危险因素的知晓率、胆固醇水平的降低、实现预防心血管疾病的健康生活方式以及降血脂药物可及性的改善等。他汀类药物在许多国家已被纳入报销政策以提高其使用率,从而预防中风和心血管疾病的发生。我们发现中国需要引入新的项目,因为现行的高脂血症管理政策并不充分。《2016年世界银行报告》建议中国的预防政策应以美国的“百万心脏”项目为蓝本。
新的高脂血症预防政策必须设定有时限的目标,在应用方面需要以患者和临床医生为中心,并定期修订以实现长期效益。