Nelson J C, Mazure C M
Am J Psychiatry. 1986 Mar;143(3):363-6. doi: 10.1176/ajp.143.3.363.
In this retrospective study the authors determined the efficacy of lithium added to a combined antipsychotic-antidepressant drug regimen in 21 psychotically depressed patients who had been refractory to combined drug treatment. Response to lithium was then compared with response rates of 15 patients to ECT, the established treatment for nonresponsive delusional depression. Lithium was effective in eight of nine patients with bipolar depression but in only three of 12 patients with unipolar depression; ECT was effective in nine of 15 patients with unipolar depression. Lithium augmentation appeared to be a realistic treatment alternative for refractory bipolar patients but was disappointing in unipolar patients.
在这项回顾性研究中，作者确定了在21例对联合药物治疗无效的精神病性抑郁症患者中，添加锂盐至抗精神病药与抗抑郁药联合治疗方案中的疗效。然后将锂盐治疗的反应率与15例接受电休克治疗（ECT）（这是治疗无反应性妄想性抑郁症的既定疗法）的患者的反应率进行比较。锂盐对9例双相抑郁症患者中的8例有效，但对12例单相抑郁症患者中仅3例有效；ECT对15例单相抑郁症患者中的9例有效。锂盐增效似乎是难治性双相情感障碍患者一种切实可行的治疗选择，但对单相抑郁症患者而言却令人失望。
