Price L H, Conwell Y, Nelson J C
Am J Psychiatry. 1983 Mar;140(3):318-22. doi: 10.1176/ajp.140.3.318.
Recent clinical studies have reported rapid improvement following administration of lithium to depressed patients who are unresponsive to tricyclic antidepressants. The clinical value of lithium augmentation would be greatest in subtypes of depression refractory to tricyclic treatment, such as delusional depression. The authors describe the results of a preliminary study of lithium augmentation in six patients with delusional depression who were unresponsive to combined neuroleptic-tricyclic treatment. Of the six, three had a dramatic response, two had a more gradual response, and one was unresponsive. The authors discuss alternative mechanisms of lithium action in these patients.
近期的临床研究报告称，对于对三环类抗抑郁药无反应的抑郁症患者，给予锂盐治疗后病情迅速改善。锂盐增效疗法在对三环类治疗难治的抑郁症亚型（如妄想性抑郁症）中的临床价值最大。作者描述了一项对6例对联合使用抗精神病药物-三环类药物治疗无反应的妄想性抑郁症患者进行锂盐增效治疗的初步研究结果。这6例患者中，3例有显著反应，2例反应较为缓慢，1例无反应。作者讨论了锂盐在这些患者中的作用的其他机制。
