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前列腺癌中aPKCλ/ι表达与患者预后之间缺乏相关性。

Lack of an association between the aPKCλ/ι expression in prostate cancer and the patient outcomes.

作者信息

Yokomizo Yumiko, Kawahara Takashi, Nagashima Yoji, Ishiguro Hitoshi, Kato Ikuma, Yao Masahiro, Miyamoto Hiroshi, Uemura Hiroji

机构信息

Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan; Departments of Urology and Renal Transplantation, Yokohama City Medical Center, Yokohama, Japan.

出版信息

Int J Surg Case Rep. 2017;37:180-182. doi: 10.1016/j.ijscr.2017.06.047. Epub 2017 Jun 29.

DOI:10.1016/j.ijscr.2017.06.047
PMID:28697433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5504077/
Abstract

• This is the first study to assess aPKCλ/ι expression in primary prostate cancer with metastatic disease. • A total of 43 patients with prostate cancer and its metastasis to the lymph node and/or bone were analyzed in this study. • We found no strong association between aPKCλ/ι expression and the prognosis of the patients.

摘要

• 这是第一项评估原发性前列腺癌伴转移疾病中aPKCλ/ι表达的研究。

• 本研究共分析了43例前列腺癌伴淋巴结和/或骨转移的患者。

• 我们发现aPKCλ/ι表达与患者预后之间没有密切关联。

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Int J Surg Case Rep. 2017;37:180-182. doi: 10.1016/j.ijscr.2017.06.047. Epub 2017 Jun 29.
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本文引用的文献

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Preferred reporting of case series in surgery; the PROCESS guidelines.外科手术病例系列报告的首选方法：PROCESS 指南。
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Aberrant Expression of the Cell Polarity Regulator aPKCλ/ι is Associated With Disease Progression in Cervical Intraepithelial Neoplasia (CIN): A Possible Marker for Predicting CIN Prognosis.
细胞极性调节因子aPKCλ/ι的异常表达与宫颈上皮内瘤变（CIN）的疾病进展相关：一种预测CIN预后的可能标志物。
Int J Gynecol Pathol. 2016 Mar;35(2):106-17. doi: 10.1097/PGP.0000000000000228.
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Treating Patients with Metastatic Castration Resistant Prostate Cancer: A Comprehensive Review of Available Therapies.治疗转移性去势抵抗性前列腺癌患者：现有疗法的全面综述
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The role of NFATc1 in prostate cancer progression: cyclosporine A and tacrolimus inhibit cell proliferation, migration, and invasion.NFATc1在前列腺癌进展中的作用：环孢素A和他克莫司抑制细胞增殖、迁移和侵袭。
Prostate. 2015 May;75(6):573-84. doi: 10.1002/pros.22937. Epub 2015 Jan 28.
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Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C λ/ι, E-cadherin, β-catenin and basement membrane component.结直肠侧向发育肿瘤表现出细胞极性因子的特征性表达，包括非典型蛋白激酶Cλ/ι、E-钙黏蛋白、β-连环蛋白和基底膜成分。
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High expression of KIBRA in low atypical protein kinase C-expressing gastric cancer correlates with lymphatic invasion and poor prognosis.KIBRA 在低表达非典型蛋白激酶 C 的胃癌中高表达与淋巴侵袭和不良预后相关。
Cancer Sci. 2013 Feb;104(2):259-65. doi: 10.1111/cas.12066. Epub 2012 Dec 27.
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Risk factors for metastatic castration-resistant prostate cancer (CRPC) predict long-term treatment with docetaxel.转移性去势抵抗性前列腺癌（CRPC）的风险因素可预测多西他赛的长期治疗效果。
PLoS One. 2012;7(10):e48186. doi: 10.1371/journal.pone.0048186. Epub 2012 Oct 30.
9
aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.非典型蛋白激酶Cλ/ι通过白细胞介素-6的转录激活以自分泌方式促进前列腺癌细胞生长。
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16369-74. doi: 10.1073/pnas.0907044106. Epub 2009 Sep 2.
10
The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors.非典型蛋白激酶Cλ/ι在乳腺癌中的过表达及定位改变与这些肿瘤的病理类型相关。
Hum Pathol. 2008 Jun;39(6):824-31. doi: 10.1016/j.humpath.2007.11.001.