Taylor D J, Yoffe J R, Brown D M, Woolley D E
Arthritis Rheum. 1986 Feb;29(2):160-5. doi: 10.1002/art.1780290202.
Histamine stimulates prostaglandin E (PGE) production by cultures of adherent rheumatoid synovial cells and human articular chondrocytes. When subcultured synovial fibroblasts or human articular chondrocytes were "primed" by preincubation with conditioned media from primary adherent rheumatoid synovial cell cultures (synovial factor), each produced even higher PGE levels upon histamine exposure. This histamine stimulation was prevented by histamine H1, but not H2, antagonists and was more marked if serum was absent from the culture media. Thus, histamine-induced PGE production by these cells is mediated via H1 receptor activation and subsequent arachidonic acid liberation.
组胺可刺激贴壁类风湿性滑膜细胞和人关节软骨细胞培养物产生前列腺素E（PGE）。当传代培养的滑膜成纤维细胞或人关节软骨细胞用来自原代贴壁类风湿性滑膜细胞培养物的条件培养基（滑膜因子）进行预孵育“预处理”后，在暴露于组胺时，它们各自产生的PGE水平更高。组胺H1拮抗剂而非H2拮抗剂可阻止这种组胺刺激，并且如果培养基中没有血清，这种刺激会更明显。因此，这些细胞由组胺诱导的PGE产生是通过H1受体激活和随后的花生四烯酸释放介导的。
