人体关节软骨细胞上存在组胺H1和H2受体的证据。
Evidence for both histamine H1 and H2 receptors on human articular chondrocytes.
作者信息
Taylor D J, Woolley D E
出版信息
Ann Rheum Dis. 1987 Jun;46(6):431-5. doi: 10.1136/ard.46.6.431.
Abstract
Using specific histamine H1 and H2 receptor antagonists, evidence is presented for the existence of both H1 and H2 receptors on human articular chondrocytes in vitro. Stimulation of the H1 receptor by histamine (range 0.18 to 17.8 mumol/l) significantly increased prostaglandin E (PGE) production, while activation of the histamine H2 receptor increased intracellular cyclic adenosine-5'-monophosphate (AMP). The histamine H1 antagonists mepyramine and tripelennamine blocked the histamine induced increase in PGE production, and the H2 antagonists cimetidine and ranitidine prevented the increase in intracellular cyclic AMP. These observations suggest that mast cell-chondrocyte interactions mediated via histamine may contribute to some of the pathophysiological changes observed in joint disease.
摘要
利用特定的组胺H1和H2受体拮抗剂，有证据表明在体外人关节软骨细胞上同时存在H1和H2受体。组胺（浓度范围为0.18至17.8 μmol/L）刺激H1受体可显著增加前列腺素E（PGE）的产生，而组胺H2受体的激活则增加细胞内的环磷酸腺苷（AMP）。组胺H1拮抗剂美吡拉敏和曲普利啶可阻断组胺诱导的PGE产生增加，H2拮抗剂西咪替丁和雷尼替丁可阻止细胞内环AMP的增加。这些观察结果表明，通过组胺介导的肥大细胞 - 软骨细胞相互作用可能促成了关节疾病中观察到的一些病理生理变化。
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