Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
University of Chinese Academy of Sciences , Beijing 100049, China.
Chem Rev. 2017 Jul 12;117(13):9433-9520. doi: 10.1021/acs.chemrev.6b00657. Epub 2017 Feb 13.
As two coexisting and fast-growing research fields in modern synthetic chemistry, the merging of organocatalysis and C-H bond functionalization is well foreseeable, and the joint force along this line has been demonstrated to be a powerful approach in making inert C-H bond functionalization more viable, predictable, and selective. In this review, we provide a comprehensive summary of organocatalysis in inert C-H bond functionalization over the past two decades. The review is arranged by types of inert C-H bonds including alkane C-H, arene C-H, and vinyl C-H as well as those activated benzylic C-H, allylic C-H, and C-H bonds alpha to the heteroatom such as nitrogen and oxygen. In each section, the discussion is classified by the explicit organocatalytic mode involved.
作为现代合成化学中两个并存且快速发展的研究领域，有机催化和 C-H 键功能化的融合是可以预见的，沿着这条线的联合力量已经被证明是使惰性 C-H 键功能化更可行、可预测和选择性更强的一种有力方法。在这篇综述中，我们对过去二十年中惰性 C-H 键功能化中的有机催化进行了全面总结。综述按照惰性 C-H 键的类型进行安排，包括烷烃 C-H、芳基 C-H 和乙烯基 C-H 以及那些活化的苄基 C-H、烯丙基 C-H 和氮和氧等杂原子α位的 C-H 键。在每一节中，讨论都是按照所涉及的明确的有机催化模式进行分类的。
