Giffin J P, Hartung J, Cottrell J E, Capuano C, Shwiry B
Br J Anaesth. 1986 Apr;58(4):441-3. doi: 10.1093/bja/58.4.441.
The effect of vecuronium on intracranial pressure (ICP) was investigated in six cats with normal and increased ICP. Cats were anaesthetized with pentobarbitone 33 mg kg-1 i.p. and acepromazine 0.6 mg kg-1 i.p., the trachea was intubated, and the lungs ventilated with nitrous oxide in oxygen. Mean arterial pressure (MAP), heart rate (HR), twitch response and ICP were recorded continuously. After the effect of vecuronium had been ascertained under the condition of normal ICP, and after full recovery of twitch response, pH-adjusted Ringer's lactate solution was infused to the cisterna magna until an ICP baseline of 26 +/- 2 mm Hg was established, and had stabilized. Vecuronium was administered again to determine its effect under the condition of increased ICP. Complete ablation of twitch response was obtained in 68 +/- 15 s with vecuronium 80 micrograms kg-1, and there was no significant change in ICP, MAP, HR or cerebral perfusion pressure (CPP) under either ICP condition.
在六只颅内压正常和升高的猫身上研究了维库溴铵对颅内压（ICP）的影响。猫经腹腔注射33mg/kg戊巴比妥和0.6mg/kg乙酰丙嗪麻醉，气管插管，并用一氧化二氮和氧气进行肺通气。连续记录平均动脉压（MAP）、心率（HR）、抽搐反应和颅内压。在正常颅内压条件下确定维库溴铵的作用后，待抽搐反应完全恢复，向枕大池输注pH值调整后的乳酸林格氏液，直至建立并稳定在26±2mmHg的颅内压基线。再次给予维库溴铵以确定其在颅内压升高条件下的作用。80μg/kg维库溴铵在68±15秒内使抽搐反应完全消失，在两种颅内压条件下，颅内压、平均动脉压、心率或脑灌注压（CPP）均无显著变化。
