Hunt P C, Cotton B R, Smith G
Anaesthesia. 1984 May;39(5):412-5. doi: 10.1111/j.1365-2044.1984.tb07306.x.
The effects of pancuronium and vecuronium on the lower oesophageal sphincter pressure were studied in 24 healthy patients anaesthetised with 0.5% halothane in nitrous oxide and oxygen. Following pancuronium 0.1 mg/kg intravenously, there was a significant increase in barrier pressure from a control value of 2.0 (SEM 0.14) kPa to 3.0 (SEM 0.27) kPa 1 minute after injection (p less than 0.05). This increase was sustained throughout the 15 minute period of recording and was accompanied by a significant increase in heart rate (p less than 0.001). Following administration of vecuronium 0.1 mg/kg intravenously there was an initial modest, though not significant increase in barrier pressure. This increase was significant (p less than 0.05) at 15 minutes. There were no cardiovascular changes following vecuronium.
在24例用0.5%氟烷、氧化亚氮和氧气麻醉的健康患者中，研究了泮库溴铵和维库溴铵对食管下括约肌压力的影响。静脉注射0.1mg/kg泮库溴铵后，注射后1分钟时屏障压从对照值2.0（标准误0.14）kPa显著增加至3.0（标准误0.27）kPa（p<0.05）。在整个15分钟的记录期间，这种增加持续存在，并伴有心率显著增加（p<0.001）。静脉注射0.1mg/kg维库溴铵后，屏障压最初有适度增加，但不显著。在15分钟时这种增加显著（p<0.05）。使用维库溴铵后未出现心血管变化。
