Wolkowitz O M, Doran A R, Breier A, Cohen M R, Pickar D
Biol Psychiatry. 1986 Apr;21(4):366-73. doi: 10.1016/0006-3223(86)90164-2.
We utilized a naloxone challenge strategy to investigate the functioning of the endogenous opioid system (EOS) in schizophrenia. Patients with schizophrenia, who were on neuroleptic medication or drug-free, demonstrated a significantly larger serum cortisol response to opioid blockade by naloxone than did age- and sex-matched normal controls. Patients, but not normal controls, also demonstrated an inverse relationship between baseline cortisol and the magnitude of the response. This enhanced cortisol response is consistent with tonic hyperactivity of the EOS in schizophrenia.
我们采用纳洛酮激发策略来研究精神分裂症患者内源性阿片系统（EOS）的功能。正在服用抗精神病药物或未服用药物的精神分裂症患者，与年龄和性别匹配的正常对照组相比，对纳洛酮阻断阿片类物质的反应表现出显著更大的血清皮质醇反应。患者（而非正常对照组）还表现出基线皮质醇与反应强度之间的负相关关系。这种增强的皮质醇反应与精神分裂症患者EOS的紧张性多动一致。
