Akhundov R A, Rozhanets V V, Voronina T A, Val'dman A V
Biull Eksp Biol Med. 1986 Mar;101(3):329-31.
The interaction of nicotinamide and its electron structural analogs (NMF and AzN compounds) with central benzodiazepine receptor antagonist Ro 15-1788 and GABA-ergic system antagonist bicuculline were studied in a conflicting situation test. NMF and AzN behaved as the agonists of GABA-benzodiazepine receptor complex. Like in diazepam, the anxiolytic effects of benzodiazepines and nicotinamide was prevented by bicuculline and Ro 15-1788. The given compounds were shown to be more active, than nicotinamide.
