Akhundov R A, Voronina T A
Farmakol Toksikol. 1984 Jul-Aug;47(4):25-8.
Psychopharmacological methods were used to study and compare the effects of diazepam and ligands of benzodiazepine receptors (inosin, nicotinamide and their structural analogs NMF and AzN) in animal experiments. It was found that they possess demonstrable sedative, anticonvulsant, antiaggressive and myorelaxant properties, inhibit the conditioned avoidance reflex in a shuttle-box and the conditioned reflex with positive (drinking) reinforcement in a T-maze. The structural analogs of nicotinamide, NMF and AzN, were found to occupy the intermediate position between diazepam and endogenous ligands of benzodiazepine receptors from the standpoint of pharmacological activity.
在动物实验中，采用心理药理学方法研究并比较了地西泮和苯二氮䓬受体配体（肌苷、烟酰胺及其结构类似物NMF和AzN）的作用。结果发现，它们具有明显的镇静、抗惊厥、抗攻击和肌松特性，能抑制穿梭箱中的条件性回避反射以及T迷宫中具有阳性（饮水）强化作用的条件反射。从药理活性角度来看，烟酰胺的结构类似物NMF和AzN处于地西泮与苯二氮䓬受体内源性配体之间的中间位置。
