儿童多发性硬化症的临床与流行病学特征
Clinical and Epidemiological Aspects of Multiple Sclerosis in Children.
作者信息
Nasehi Mohammad Mehdi, Sahraian Mohammad Ali, Naser Moghadasi Abdorreza, Ghofrani Mohammad, Ashtari Fereshteh, Taghdiri Mohammad Mahdi, Tonekaboni Seyed Hassan, Karimzadeh Parvaneh, Afshari Mahdi, Moosazadeh Mahmood
机构信息
Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pediatric Neurology Excellence Center, Pediatric Neurology Department, Mofi Children Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Child Neurol. 2017 Spring;11(2):37-43.
OBJECTIVE
Overall, 2%-5% of patients with multiple sclerosis (MS) experienced the first episode of disease before the age 18 years old. Since the age of onset among children is not similar to that in general population, clinicians often fail to early diagnose the disease. This study aimed to determine the epidemiological and clinical patterns of MS among Iranian children.
MATERIALS & METHODS: In this cross-sectional study carried out in Iran in 2014-2015, information was collected using a checklist with approved reliability and validity. Method sampling was consensus. Data were analyzed using frequency, mean and standard deviation indices by means of SPSS ver. 20 software.
RESULTS
Totally, 177 MS children were investigated. 75.7% of them were female. Mean (SD), minimum and maximum age of subjects were 15.9 (2), 7 and 18 yr, respectively. The most reported symptoms were sensory (28.2%), motor (29.4%), diplopia (20.3%) and visual (32.8%). Primary MRI results showed 91.5% and 53.1% periventricular and spinal cord lesions, respectively.
CONCLUSION
MS is significantly more common among women. The most common age of onset is during the second decades. Sensory and motor problems are the most symptoms, while, periventricular and spinal cord lesions are the most MRI results.
目的
总体而言，2% - 5%的多发性硬化症（MS）患者在18岁之前经历了疾病的首次发作。由于儿童的发病年龄与普通人群不同，临床医生常常无法早期诊断该疾病。本研究旨在确定伊朗儿童MS的流行病学和临床模式。
材料与方法
在2014 - 2015年于伊朗开展的这项横断面研究中，使用具有认可信效度的检查表收集信息。方法抽样为共识抽样。通过SPSS 20版软件使用频率、均值和标准差指标对数据进行分析。
结果
总共调查了177名MS儿童。其中75.7%为女性。受试者的平均（标准差）年龄、最小年龄和最大年龄分别为15.9（2）岁、7岁和18岁。报告最多的症状为感觉症状（28.2%）、运动症状（29.4%）、复视（20.3%）和视觉症状（32.8%）。初次MRI结果显示，脑室周围病变和脊髓病变分别为91.5%和53.1%。
结论
MS在女性中明显更为常见。最常见的发病年龄在第二个十年。感觉和运动问题是最常见的症状，而脑室周围和脊髓病变是最常见的MRI结果。
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