Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.
Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, Anhui, China.
Clin Rheumatol. 2017 Oct;36(10):2193-2200. doi: 10.1007/s10067-017-3747-x. Epub 2017 Jul 11.
This study aimed to systemically review the evidence regarding the relationship between the circulating blood osteoprotegerin (OPG) level and rheumatoid arthritis (RA), as well as the potential influential factors. Research related to plasma/serum OPG levels in RA patients and healthy controls were gathered using PubMed, EMBASE, and The Cochrane Library database (up to Jan. 1, 2017). Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by fixed-effects or random-effect model analysis. Heterogeneity test was performed by the Q statistic and quantified using I , and publication bias was evaluated using a funnel plot and Egger's linear regression test. After searching databases, 443 articles were obtained, and 11 studies with 710 RA patients and 561 controls were finally included. Meta-analysis revealed that, compared with the control group, the OPG level was significantly higher in the RA group (P < 0.001), with the SMD of 1.02 and 95%CI (0.20, 1.84). Subgroup analyses showed that race, disease duration, body mass index (BMI), and disease activity score based on the assessment of 28 joints (DAS28) were positively associated with OPG level in RA patients. Our meta-analysis revealed a significantly higher circulating OPG level in RA patients, and it was influenced by race, disease duration, BMI, and DAS28.
本研究旨在系统回顾关于循环血液护骨素（OPG）水平与类风湿关节炎（RA）之间关系的证据，以及潜在的影响因素。使用 PubMed、EMBASE 和 The Cochrane Library 数据库（截至 2017 年 1 月 1 日）收集了与 RA 患者和健康对照者血浆/血清 OPG 水平相关的研究。采用固定效应或随机效应模型分析计算合并标准化均数差（SMD）及其 95%置信区间（CI）。采用 Q 检验进行异质性检验，并采用 I 2 进行量化，采用漏斗图和 Egger 线性回归检验评估发表偏倚。检索数据库后获得 443 篇文章，最终纳入 11 项研究，共纳入 710 例 RA 患者和 561 例对照者。Meta 分析显示，与对照组相比，RA 组 OPG 水平显著升高（P < 0.001），SMD 为 1.02，95%CI（0.20，1.84）。亚组分析显示，种族、疾病持续时间、体重指数（BMI）和基于 28 个关节评估的疾病活动评分（DAS28）与 RA 患者的 OPG 水平呈正相关。本 Meta 分析表明 RA 患者循环 OPG 水平显著升高，且受种族、疾病持续时间、BMI 和 DAS28 的影响。
