Sharma P, Sahu K, Kushwaha P K, Kumar S, Swami M K, Kumawat J, Patel H S, Kher S, Sahani P K, Haridas G, Gupta P K
Laser Biomedical Applications Section, Raja Ramanna Centre for Advanced Technology, Indore, India.
Homi Bhabha National Institute, Mumbai, India.
Lasers Med Sci. 2017 Sep;32(7):1535-1544. doi: 10.1007/s10103-017-2276-9. Epub 2017 Jul 11.
We report the results of a study carried out to investigate the potential of optical techniques such as optical coherence tomography, Mueller matrix spectroscopy, and cross-polarization imaging for noninvasive monitoring of the ionizing radiation exposure-induced alterations in cutaneous tissue of mice. Radiation dose-dependent changes were observed in tissue microvasculature and tissue optical parameters like retardance and depolarization as early as 1 h post radiation exposure. Results suggest that these optical techniques may allow early detection of radiation dose-dependent alterations which could help in screening of population exposed to radiation.
我们报告了一项研究的结果，该研究旨在调查光学相干断层扫描、穆勒矩阵光谱学和交叉偏振成像等光学技术在无创监测小鼠皮肤组织中电离辐射暴露引起的变化方面的潜力。早在辐射暴露后1小时，就观察到组织微血管系统以及诸如延迟和去极化等组织光学参数的辐射剂量依赖性变化。结果表明，这些光学技术可能有助于早期检测辐射剂量依赖性变化，这有助于对受辐射人群进行筛查。
