阿霉素（阿霉素）诱导的幼火鸡心脏毒性：一种动物模型。

Doxorubicin (adriamycin)-induced cardiotoxicity in turkey poults: an animal model.

作者信息

Czarnecki C M

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1986;83(1):53-60. doi: 10.1016/0742-8413(86)90012-5.

Abstract

Doxorubicin (adriamycin, ADR)-induced cardiomyopathy was produced in turkey poults in a period of 3 weeks. The cardiotoxicity is characterized by electrocardiographic changes, alterations in ultrastructural morphology, ventricular dilatation, a significantly increased number of heterophils, and significant decreases in body and heart weights, dry heart weight to body weight ratios, and number of non-granulocytic leukocytes. The turkey poult is a cost-effective model system for evaluating cardiotoxic effects of anthracycline drugs.

摘要

在3周的时间里，给小火鸡雏造成了阿霉素（阿霉素，ADR）诱导的心肌病。这种心脏毒性的特征是心电图改变、超微结构形态改变、心室扩张、嗜异性粒细胞数量显著增加，以及体重、心脏重量、心脏干重与体重之比和非粒细胞白细胞数量显著减少。小火鸡雏是评估蒽环类药物心脏毒性作用的一种经济高效的模型系统。