向达西·温特沃斯·汤普森致敬：阐明一项发育原理。
A tribute to D'Arcy Wentworth Thompson: Elucidation of a developmental principle.
作者信息
Durston Antony J, Zhu Kongju
机构信息
Sylvius Laboratory, Institute of Biology, University of Leiden, Leiden, The Netherlands.
出版信息
Bioessays. 2017 Aug;39(8). doi: 10.1002/bies.201700088. Epub 2017 Jul 12.
PMID:28699180
Abstract
We show the vertebrate anterior -posterior axis is made by time space translation (TST). 1/ TST of Hox temporal to spatial collinearity makes the trunk part of the axis. 2/TST continues into the head. 3/ TST is mediated by collinear Hox-Hox interactions. 4/ 'Decision points' involving signalling pathways separate axial domains.
摘要
我们证明脊椎动物的前后轴是由时空转换（TST）形成的。1/Hox基因从时间共线性到空间共线性的时空转换形成了轴的躯干部分。2/时空转换延伸至头部。3/时空转换由共线性的Hox-Hox相互作用介导。4/涉及信号通路的“决策点”分隔了轴的各个区域。
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