钙依赖性自发性神经递质释放。
Calcium dependence of spontaneous neurotransmitter release.
机构信息
Department of Medicine, Division of Pulmonary & Critical Care Medicine, Oregon Health & Science University, Portland, Oregon.
Section of Pulmonary & Critical Care Medicine, VA Portland Health Care System, Portland, Oregon.
出版信息
J Neurosci Res. 2018 Mar;96(3):335-347. doi: 10.1002/jnr.24116. Epub 2017 Jul 12.
Abstract
Spontaneous release of neurotransmitters is regulated by extracellular [Ca ] and intracellular [Ca ]. Curiously, some of the mechanisms of Ca signaling at central synapses are different at excitatory and inhibitory synapses. While the stochastic activity of voltage-activated Ca channels triggers a majority of spontaneous release at inhibitory synapses, this is not the case at excitatory nerve terminals. Ca release from intracellular stores regulates spontaneous release at excitatory and inhibitory terminals, as do agonists of the Ca -sensing receptor. Molecular machinery triggering spontaneous vesicle fusion may differ from that underlying evoked release and may be one of the sources of heterogeneity in release mechanisms.
摘要
神经递质的自发释放受细胞外 [Ca ] 和细胞内 [Ca ] 的调节。奇怪的是，中枢突触的钙信号转导机制在兴奋性和抑制性突触中有所不同。虽然电压激活钙通道的随机活动触发了抑制性突触中大多数自发释放，但在兴奋性神经末梢则并非如此。细胞内储存的 Ca 释放调节兴奋性和抑制性末梢的自发释放，钙敏感受体激动剂也是如此。触发自发囊泡融合的分子机制可能与引发释放的机制不同，可能是释放机制异质性的来源之一。
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