1 Unit of Molecular Metabolism, Department of Clinical Sciences in Malmö Lund University , Malmö, Sweden .
2 Department of Endocrinology, Skåne University Hospital , Malmö, Sweden .
Thyroid. 2017 Sep;27(9):1109-1117. doi: 10.1089/thy.2017.0218. Epub 2017 Aug 18.
Hyperthyroidism is associated with alterations in metabolism that are currently only partially understood. The objective of the study was to investigate changes in metabolism associated with reinstatement of euthyroidism in Swedish patients.
Eighty metabolites in plasma were profiled from 10 subjects with Graves' disease (GD) at baseline and after 9 and 15 months of treatment to reinstate euthyroidism. Thyroid parameters, thyrotropin (TSH), TSH receptor antibodies, free triiodothyronine, and free thyroxine were followed. Main findings were validated in plasma from 20 subjects with GD at baseline and at three, six, and nine months. The study was conducted at the endocrinology clinic in Malmö, Sweden.
Euthyroidism was reinstated at three months, and thyroid status did not change further during the 15-month follow-up. This was paralleled by altered levels of 9/19 detected acylcarnitines (p < 0.05 after adjustment for multiple testing). Levels of short-chain acylcarnitines were decreased, intermediate-chain acylcarnitines elevated, and long-chain acylcarnitines unaltered.
GD and treatment of the disease is associated with pronounced acyl chain length-dependent alterations in acylcarnitine levels. These changes may be impacted by ethnicity and or dietary differences.
甲状腺功能亢进症与代谢改变有关，目前这些改变仅部分被了解。本研究旨在调查在瑞典甲状腺功能亢进症患者恢复甲状腺功能正常时与代谢相关的改变。
从 10 例格雷夫斯病（GD）患者中检测了基线时和治疗后 9 个月和 15 个月的 80 种血浆代谢物，以恢复甲状腺功能正常。检测了甲状腺参数、促甲状腺激素（TSH）、TSH 受体抗体、游离三碘甲状腺原氨酸和游离甲状腺素。主要发现结果在基线和 3、6 和 9 个月时的 20 例 GD 患者的血浆中进行了验证。该研究在瑞典马尔默的内分泌科诊所进行。
甲状腺功能正常在 3 个月时恢复，在 15 个月的随访期间甲状腺状态没有进一步变化。这与 9/19 种检测到的酰基辅酶 A（在经过多次检测调整后 p<0.05）的水平改变相一致。短链酰基辅酶 A 的水平降低，中间链酰基辅酶 A 的水平升高，长链酰基辅酶 A 的水平不变。
GD 和疾病的治疗与酰基辅酶 A 水平的显著的酰链长度依赖性改变有关。这些变化可能受到种族和/或饮食差异的影响。
