Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
Curr Pharm Des. 2017;23(35):5242-5260. doi: 10.2174/1381612823666170710121900.
Polymer micellar nanogels are a group of core-shell polymeric micelles with swelling properties in aqueous media. Nanogel systems have proven their potential in controlled, sustained and targetable drug delivery area with no immunological responses. This review includes a comprehensive wide range of self-assembly of polymeric nanogels as delivery systems for anticancer drugs. Nanogels are nanoparticulate drug delivery systems which are specially designed for enhanced target oriented and cellular uptake of drugs with emphasis on chemotherapeutic agents studied in this review. Self-assembling nanogels are based on natural substances or synthetic polymers including: hyaluronic acid, heparin, alginate, cyclodextrins, chondroeitin sulfate, starch, mannan, chitosan, pullulan, poly(N-isopropylacrylamide), polyvynil alcohol, Pluronic F127, polyacrylic acid, poly(hydroxylethyl methacrylate), poly[2- (dimethylamino)ethyl methacrylate and polylactide-co-glycolide-polyethylen glycol amphiphilic di or tri block copolymer used to deliver anticancer drugs are introduced and discussed.
聚合物胶束纳米凝胶是一组具有在水介质中溶胀性能的核壳型聚合物胶束。纳米凝胶系统已在无免疫反应的控制、持续和靶向药物递送领域证明了其潜力。本综述包括作为抗癌药物递送系统的聚合物纳米凝胶的广泛的自组装。纳米凝胶是纳米颗粒药物递送系统，专门设计用于增强药物的靶向和细胞摄取，重点研究本综述中研究的化疗药物。自组装纳米凝胶基于天然物质或合成聚合物，包括：透明质酸、肝素、藻酸盐、环糊精、软骨素硫酸盐、淀粉、甘露聚糖、壳聚糖、普鲁兰、聚（N-异丙基丙烯酰胺）、聚乙烯醇、泊洛沙姆 F127、聚丙烯酸、聚（羟乙基甲基丙烯酸酯）、聚[2-（二甲氨基）乙基甲基丙烯酸酯]和聚乳酸-共-羟基乙酸-聚乙二醇两亲性二或三嵌段共聚物用于递送抗癌药物的介绍和讨论。
