Kousalová J, Etrych T
Department of Biomedicinal Polymers, Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Prague 6, Czech Republic.
Physiol Res. 2018 Oct 30;67(Suppl 2):S305-S317. doi: 10.33549/physiolres.933979.
The present review focuses on the description of the design, synthesis and physico-chemical and biological evaluation of polymer nanogels. Nanogels are robust swollen cross-linked polymer nanoparticles that can be used as highly efficient and biodegradable carriers for the transport of drugs in controlled drug delivery. In this article, various types of nanogels are described and methods for their preparation discussed. The possibility of using synthesized nanosystems for targeting are reviewed to show the potential of tailored structures to reach either solid tumor tissue or direct tumor cells. Finally, the methods for encapsulation or attachment of biologically active molecules, e.g. drugs, proteins, are described and compared.
本综述着重描述聚合物纳米凝胶的设计、合成以及物理化学和生物学评价。纳米凝胶是坚固的溶胀交联聚合物纳米颗粒，可作为高效且可生物降解的载体，用于控释给药中的药物运输。本文描述了各种类型的纳米凝胶，并讨论了其制备方法。综述了使用合成纳米系统进行靶向的可能性，以展示定制结构到达实体肿瘤组织或直接作用于肿瘤细胞的潜力。最后，描述并比较了封装或连接生物活性分子（如药物、蛋白质）的方法。
