根治性子宫切除术后β-肾上腺素能刺激对膀胱和尿道的影响。

The effect of beta-adrenergic stimulation on the bladder and urethra following radical hysterectomy.

作者信息

Kerr-Wilson R H, Orr J W, Shingleton H M, Hatch K D, Trammel M W

出版信息

Gynecol Oncol. 1986 Mar;23(3):267-74. doi: 10.1016/0090-8258(86)90126-5.

Abstract

The effect of two beta-adrenergic stimulating agents on bladder and urethral function was assessed in 16 patients 3 weeks after radical hysterectomy for carcinoma of the cervix. Urodynamic evaluation was performed before and after inhalation of metaproterenol by metered dose inhaler in 10 patients and injection of 0.25 mg of terbutaline sc in 6 patients. Although no change was observed following administration of metaproterenol, a significant decrease in maximum urethral pressure and urethral closure pressure, and a significant increase in volume of urine voided was found after administration of terbutaline. These results suggest that beta-sympathomimetic agents may benefit those patients with bladder dysfunction following radical hysterectomy.

摘要

在16例因宫颈癌行根治性子宫切除术后3周的患者中，评估了两种β-肾上腺素能兴奋剂对膀胱和尿道功能的影响。对10例患者通过定量吸入器吸入间羟异丙肾上腺素，对6例患者皮下注射0.25mg特布他林，分别在用药前后进行尿动力学评估。虽然吸入间羟异丙肾上腺素后未观察到变化，但注射特布他林后发现最大尿道压和尿道闭合压显著降低，排尿量显著增加。这些结果表明，β-拟交感神经药可能对根治性子宫切除术后膀胱功能障碍的患者有益。