Sun Y W, Zhou Y X, Ding D P
Hear Res. 1986;21(1):83-6. doi: 10.1016/0378-5955(86)90049-3.
The scala tympani of the guinea pig was perfused with artificial perilymph and experimental solutions using an electrical micropump. In test perfusions, 20 mM L-aspartate produced depression of APN1 by 49% and 25 mM L-aspartate decreased the amplitude of APN1 by 42%. Both 20 mM and 25 mM L-aspartate were without effect on the CM, the latency or width of APN1. Perfusions with 10 mM oxaloacetic acid were without effect on the APN1 and CM. In our previous experiments, 5 mM L-aspartate had no effect on APN1 and CM, but 10 mM L-aspartate or 15 mM L-aspartate introduced into the scala tympani reversibly increased the amplitude of APN1 and CM. It is concluded that L-aspartate may have a modulating influence on signal transmission of afferent synapses in the cochlea.
使用电动微量泵向豚鼠的鼓阶灌注人工外淋巴液和实验溶液。在测试灌注中，20 mM的L-天冬氨酸使APN1的幅度降低了49%，而25 mM的L-天冬氨酸使APN1的幅度降低了42%。20 mM和25 mM的L-天冬氨酸对CM、APN1的潜伏期或宽度均无影响。用10 mM草酰乙酸灌注对APN1和CM均无影响。在我们之前的实验中，5 mM的L-天冬氨酸对APN1和CM无影响，但引入鼓阶的10 mM L-天冬氨酸或15 mM L-天冬氨酸可使APN1和CM的幅度可逆性增加。得出的结论是，L-天冬氨酸可能对耳蜗传入突触的信号传递具有调节作用。
