Ikeda K, Kusakari J, Kawamoto K
Ann Otol Rhinol Laryngol. 1987 Mar-Apr;96(2 Pt 1):182-6. doi: 10.1177/000348948709600209.
The effect of nitrogen mustard-N-oxide (NMO) upon the click and tone burst-evoked N1 latency was examined in 14 albino guinea pigs. In all animals except one, the pseudothresholds of action potentials were elevated, especially in the high tone area. In addition to the amplitude reduction, the N1 latency was prolonged in 12 animals. The narrow band analysis of N1 revealed that the latency was equally prolonged in all frequency areas, although the amount of the amplitude reduction was much larger in the high frequency area. It was concluded that the prolongation of the N1 latency in NMO-treated animals was due to dysfunction of outer hair cells along the entire cochlear partition.
在14只白化豚鼠中研究了氮芥-N-氧化物（NMO）对咔嗒声和短纯音诱发的N1潜伏期的影响。除一只动物外，在所有动物中，动作电位的假阈值均升高，尤其是在高音区域。除了振幅降低外，12只动物的N1潜伏期延长。N1的窄带分析显示，尽管高频区域的振幅降低量要大得多，但所有频率区域的潜伏期均同样延长。得出的结论是，NMO处理动物中N1潜伏期的延长是由于沿整个耳蜗隔的外毛细胞功能障碍所致。
