Yang Tae Won, Park Hyun Oh, Jang Ha Nee, Yang Jun Ho, Kim Sung Hwan, Moon Seong Ho, Byun Joung Hun, Lee Chung Eun, Kim Jong Woo, Kang Dong Hun
Department of Neurology Department of Thoracic and Cardiovascular Surgery, Gyeongsang National University Changwon Hospital Department of Nephrology Department of Thoracic and Cardiovascular Surgery, College of Medicine and Institute of Health Sciences, Gyeongsang National University Hospital, Korea.
Medicine (Baltimore). 2017 Jul;96(28):e7482. doi: 10.1097/MD.0000000000007482.
Patients with drug-susceptible tuberculosis (TB) show good tolerance of the medications used and have few side effects. However, medications used to treat multidrug-resistant tuberculosis (MDR-TB) have many known side effects. Here, we studied the occurrence of side effects due to treatment of patients with MDR-TB.We conducted a retrospective and consecutive review of the medical records of 256 patients who received treatment for MDR-TB between January 2006 and December 2011.One or more side effects were observed in 95 (37.1%) of the 256 patients. These side effects led to the suspension of the use of 1 or more drugs from the regimen of individualized treatment prescribed for 44 of the patients (17.2%). The side effects observed most frequently included gastrointestinal disturbance (18.4%), psychiatric disorder (5.5%), arthralgia (4.7%), hepatitis (3.9%), peripheral neuropathy (3.1%), hypothyroidism (2.3%), epileptic seizures (2%), dermatological effects (2%), ototoxicity (1.6%), and nephrotoxicity (1.2%). The treatment was successful in 220 (85.9%) patients with MDR-TB.Our study may help in formulating strategies for the timely and aggressive management of drug side effects. This may reduce the suspension of therapy and increase the rate of clinical success.
药物敏感型肺结核患者对所用药物耐受性良好，副作用较少。然而，用于治疗耐多药肺结核（MDR-TB）的药物有许多已知的副作用。在此，我们研究了耐多药肺结核患者治疗过程中副作用的发生情况。我们对2006年1月至2011年12月期间接受耐多药肺结核治疗的256例患者的病历进行了回顾性连续分析。256例患者中有95例（37.1%）出现了一种或多种副作用。这些副作用导致44例患者（17.2%）个体化治疗方案中的1种或多种药物停用。最常观察到的副作用包括胃肠道紊乱（18.4%）、精神障碍（5.5%）、关节痛（4.7%）、肝炎（3.9%）、周围神经病变（3.1%）、甲状腺功能减退（2.3%）、癫痫发作（2%）、皮肤影响（2%）、耳毒性（1.6%）和肾毒性（1.2%）。220例（85.9%）耐多药肺结核患者治疗成功。我们的研究可能有助于制定药物副作用及时积极管理的策略。这可能会减少治疗中断并提高临床成功率。
