Clements D, Rhodes J M, Elias E
J Hepatol. 1986;2(2):262-6. doi: 10.1016/s0168-8278(86)80085-x.
The effect of a single bolus of somatostatin on oesophageal variceal pressure has been studied in 7 patients with cirrhosis and 5 patients with non-cirrhotic portal hypertension using a non-invasive variceal pressure gauge. Both groups of patients demonstrated similar reductions in variceal pressure with all subjects demonstrating a fall. The timing, duration and magnitude of this reduction in variceal pressure in response to somatostatin showed considerable individual variation which may explain the previous reports of a variable response to treatment of variceal haemorrhage with somatostatin. This individual variation should be borne in mind in the planning of future studies in the treatment of oesophageal variceal haemorrhage. The pneumatic pressure gauge allows the non-invasive study of the effects of drugs on variceal and portal pressure.
使用非侵入性静脉曲张压力计，对7例肝硬化患者和5例非肝硬化门静脉高压患者研究了单次推注生长抑素对食管静脉曲张压力的影响。两组患者的静脉曲张压力均有相似程度的降低，所有受试者的压力均出现下降。生长抑素引起的静脉曲张压力降低的时间、持续时间和幅度存在相当大的个体差异，这可能解释了先前关于生长抑素治疗静脉曲张出血反应不一的报道。在规划未来食管静脉曲张出血治疗的研究时应考虑到这种个体差异。气压计可用于对药物对静脉曲张和门静脉压力影响的非侵入性研究。
