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生长抑素不能降低肝硬化患者的食管静脉曲张压力。

Somatostatin does not reduce oesophageal variceal pressure in liver cirrhotics.

作者信息

Kleber G, Sauerbruch T, Fischer G, Paumgartner G

机构信息

Department of Medicine II, Klinikum Grosshadern, University of Munich, FRG.

出版信息

Gut. 1988 Feb;29(2):153-6. doi: 10.1136/gut.29.2.153.

DOI:10.1136/gut.29.2.153
PMID:2894336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1433282/
Abstract

Transmural oesophageal variceal pressure was determined by direct puncture of the varices in 27 patients with liver cirrhosis and oesophageal varices. Variceal pressure was not influenced three to six minutes after somatostatin bolus administration and slightly increased during somatostatin infusion. Thus, potential haemostatic benefits of somatostatin cannot be explained by pressure reductions in the varices.

摘要

对27例肝硬化合并食管静脉曲张患者，通过直接穿刺静脉曲张测定其跨壁食管静脉曲张压力。给予生长抑素推注后3至6分钟，静脉曲张压力未受影响，而在生长抑素输注期间略有升高。因此，生长抑素潜在的止血益处不能用静脉曲张压力降低来解释。

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本文引用的文献

1
Effect of somatostatin on splanchnic hemodynamics in patients with cirrhosis of the liver and in normal subjects.生长抑素对肝硬化患者及正常受试者内脏血流动力学的影响。
Gastroenterology. 1981 Mar;80(3):526-32.
2
Effects of somatostatin on hepatic and systemic hemodynamics in patients with cirrhosis of the liver: comparison with vasopressin.生长抑素对肝硬化患者肝脏及全身血流动力学的影响：与血管加压素的比较。
Gastroenterology. 1981 Mar;80(3):518-25.
3
Transection of the oesophagus for bleeding oesophageal varices.为治疗食管静脉曲张出血而行食管横断术。
Br J Surg. 1973 Aug;60(8):646-9. doi: 10.1002/bjs.1800600817.
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Prognostic significance of serum bile acids in cirrhosis.
Hepatology. 1986 Jan-Feb;6(1):50-3. doi: 10.1002/hep.1840060110.
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Intravascular oesophageal variceal pressure (IOVP) assessed by endoscopic fine needle puncture under basal conditions, Valsalva's manoeuvre and after glyceryltrinitrate application.在基础状态、瓦尔萨尔瓦动作及应用硝酸甘油后，通过内镜细针穿刺评估血管内食管静脉曲张压力（IOVP）。
Gut. 1985 May;26(5):525-30. doi: 10.1136/gut.26.5.525.
6
Effect of somatostatin on oesophageal variceal pressure assessed by direct measurement.通过直接测量评估生长抑素对食管静脉曲张压力的影响。
J Hepatol. 1986;2(2):262-6. doi: 10.1016/s0168-8278(86)80085-x.
7
Effects of a somatostatin analogue SMS 201-995 on hepatic haemodynamics in the pig and on intravariceal pressure in man.生长抑素类似物SMS 201-995对猪肝脏血流动力学及人曲张静脉内压力的影响。
Br J Surg. 1985 Dec;72(12):1009-12. doi: 10.1002/bjs.1800721225.
8
A prospective randomised controlled clinical trial comparing somatostatin and vasopressin in controlling acute variceal haemorrhage.一项比较生长抑素和血管加压素控制急性静脉曲张出血效果的前瞻性随机对照临床试验。
Br Med J (Clin Res Ed). 1985 Jan 26;290(6464):275-8. doi: 10.1136/bmj.290.6464.275.
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Treatment of bleeding oesophageal varices with somatostatin.用生长抑素治疗食管静脉曲张出血
Acta Chir Scand. 1979;145(6):395-8.
10
Somatostatin not helpful in bleeding esophageal varices.生长抑素对食管静脉曲张出血无效。
N Engl J Med. 1979 Mar 29;300(13):736-7. doi: 10.1056/NEJM197903293001317.