Panni Simona, Prakash Ananth, Bateman Alex, Orchard Sandra
Università della Calabria, Dipartimento di Biologia, Ecologia e Scienze della Terra, Rende 87036, Italy.
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
RNA. 2017 Oct;23(10):1479-1492. doi: 10.1261/rna.060996.117. Epub 2017 Jul 12.
This article describes the creation of the first expert manually curated noncoding RNA interaction networks for The RNA-RNA and RNA-protein interaction networks have been carefully extracted from the experimental literature and made available through the IntAct database (www.ebi.ac.uk/intact). We provide an initial network analysis and compare their properties to the much larger protein-protein interaction network. We find that the proteins that bind to ncRNAs in the network contain only a small proportion of classical RNA binding domains. We also see an enrichment of WD40 domains suggesting their direct involvement in ncRNA interactions. We discuss the challenges in collecting noncoding RNA interaction data and the opportunities for worldwide collaboration to fill the unmet need for this data.
本文描述了首个由专家手动策划的非编码RNA相互作用网络的创建。RNA-RNA和RNA-蛋白质相互作用网络已从实验文献中仔细提取，并通过IntAct数据库（www.ebi.ac.uk/intact）提供。我们进行了初步的网络分析，并将它们的特性与大得多的蛋白质-蛋白质相互作用网络进行比较。我们发现，网络中与非编码RNA结合的蛋白质仅包含一小部分经典RNA结合结构域。我们还发现WD40结构域富集，表明它们直接参与非编码RNA相互作用。我们讨论了收集非编码RNA相互作用数据的挑战以及全球合作填补这一数据未满足需求的机会。
