迈向分子相互作用统一的开放获取数据集。
Towards a unified open access dataset of molecular interactions.
机构信息
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton, Cambridge, CB10 1SD, UK.
SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, CH-1211, Geneva, Switzerland.
出版信息
Nat Commun. 2020 Dec 1;11(1):6144. doi: 10.1038/s41467-020-19942-z.
The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats. Additionally, we provide examples of how IMEx data are being used by biomedical researchers and integrated in other bioinformatic tools and resources.
国际分子交换（IMEx）联盟为科学家提供了一个经过实验验证的蛋白质相互作用的单一数据集，这些数据集按照国际协议的标准进行了详细的注释。在这个更新的版本中，我们将讨论该计划在实践中的运作方式，如何确保数据库的可持续性，以及如何通过引入新的交互作用类型和数据格式来应对新的注释挑战。此外，我们还提供了一些示例，说明生物医学研究人员如何使用 IMEx 数据，并将其集成到其他生物信息学工具和资源中。
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