Pharmacokinetic/Pharmacodynamic Modeling of Tulathromycin against in a Porcine Tissue Cage Model.

Tulathromycin, a macrolide antibiotic, is used for the treatment of respiratory disease in cattle and swine. The aim of our study was to investigate the and activities of tulathromycin in serum, (non-inflamed) transudate, and (inflamed) exudate against in piglets. The pharmacokinetics properties of tulathromycin were studied for serum, transudate, and exudate using a tissue cage model. antibiotic susceptibility of and dynamic time-kill curve experiments over eight tulathromycin concentrations were determined. The ratio of 24-h area under the concentration-time curve to minimum inhibitory concentration [AUC/MIC] was recognized as an important pharmacokinetic/pharmacodynamic (PK/PD) parameter of tulathromycin for antibacterial efficiency ( = 0.9969). In serum , for bacteriostatic, bactericidal activity, and virtual bacterial eradication AUC/MIC values for tulathromycin were 44.55, 73.19, and 92.44 h by using sigmoid model WinNonlin software, respectively, and lower values were obtained for exudate and transudate. In conjunction with the data on MIC, the dose of tulathromycin for a bacteriostatic effect and virtual elimination of as computed using the value of the PK/PD breakpoint obtained in serum were 6.39 and 13.25 mg/kg. However, it would be preferable to calculate a dose combined with population pharmacokinetics data to optimize the dosage regimen for bacteriological and clinical cure.