Liu Zhi Zhao, Bullen Alexander, Li Ying, Singh Prabhleen
Division of Nephrology-Hypertension, University of California San Diego School of Medicine, VA San Diego Healthcare SystemSan Diego, CA, United States.
Front Physiol. 2017 Jun 28;8:385. doi: 10.3389/fphys.2017.00385. eCollection 2017.
Chronic kidney disease (CKD) is a significant health problem associated with high morbidity and mortality. Despite significant research into various pathways involved in the pathophysiology of CKD, the therapeutic options are limited in diabetes and hypertension induced CKD to blood pressure control, hyperglycemia management (in diabetic nephropathy) and reduction of proteinuria, mainly with renin-angiotensin blockade therapy. Recently, renal oxygenation in pathophysiology of CKD progression has received a lot of interest. Several advances have been made in our understanding of the determinants and regulators of renal oxygenation in normal and diseased kidneys. The goal of this review is to discuss the alterations in renal oxygenation (delivery, consumption and tissue oxygen tension) in pre-clinical and clinical studies in diabetic and hypertensive CKD along with the underlying mechanisms and potential therapeutic options.
慢性肾脏病（CKD）是一个与高发病率和死亡率相关的重大健康问题。尽管对CKD病理生理学中涉及的各种途径进行了大量研究，但在糖尿病和高血压所致CKD中，治疗选择仅限于血压控制、高血糖管理（在糖尿病肾病中）以及主要通过肾素-血管紧张素阻断疗法减少蛋白尿。最近，CKD进展病理生理学中的肾脏氧合受到了广泛关注。在我们对正常和患病肾脏中肾脏氧合的决定因素和调节因子的理解方面已经取得了一些进展。本综述的目的是讨论糖尿病和高血压CKD的临床前和临床研究中肾脏氧合（输送、消耗和组织氧张力）的改变，以及潜在的机制和治疗选择。
