Wändell Per, Carlsson Axel C, Li Xinjun, Gasevic Danijela, Ärnlöv Johan, Holzmann Martin J, Sundquist Jan, Sundquist Kristina
Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden.
Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
Eur J Epidemiol. 2017 Sep;32(9):785-796. doi: 10.1007/s10654-017-0283-6. Epub 2017 Jul 12.
To study the association between country of birth and incident atrial fibrillation (AF) in several immigrant groups in Sweden. The study population included all adults (n = 3,226,752) aged 45 years and older in Sweden. AF was defined as having at least one registered diagnosis of AF in the National Patient Register. The incidence of AF in different immigrant groups, using Swedish-born as referents, was assessed by Cox regression, expressed in hazard ratios (HRs) and 95% confidence intervals (CI). All models were stratified by sex and adjusted for age, geographical residence in Sweden, educational level, marital status, and neighbourhood socioeconomic status. Compared to their Swedish-born counterparts, higher incidence of AF [HR (95% CI)] was observed among men from Bosnia 1.74 (1.56-1.94) and Latvia 1.29 (1.09-1.54), and among women from Iraq 1.96 (1.67-2.31), Bosnia 1.88 (1.61-1.94), Finland 1.14 (1.11-1.17), Estonia 1.14 (1.05-1.24) and Germany 1.08 (1.03-1.14). Lower incidence of AF was noted among men (HRs ≤ 0.60) from Iceland, Southern Europe (especially Greece, Italy and Spain), Latin America (especially Chile), Africa, Asia (including Iraq, Turkey, Lebanon and Iran), and among women from Nordic countries (except Finland), Southern Europe, Western Europe (except Germany), Africa, North America, Latin America, Iran, Lebanon and other Asian countries (except Turkey and Iraq). In conclusion, we observed substantial differences in incidence of AF between immigrant groups and the Swedish-born population. A greater awareness of the increased risk of AF development in some immigrant groups may enable for a timely diagnosis, treatment and prevention of its debilitating complications, such as stroke.
研究瑞典几个移民群体的出生国与房颤(AF)发病率之间的关联。研究人群包括瑞典所有45岁及以上的成年人(n = 3,226,752)。房颤定义为在国家患者登记册中至少有一次房颤的登记诊断。以瑞典出生的人群为参照,通过Cox回归评估不同移民群体的房颤发病率,以风险比(HRs)和95%置信区间(CI)表示。所有模型均按性别分层,并对年龄、瑞典的地理居住地区、教育水平、婚姻状况和邻里社会经济地位进行了调整。与瑞典出生的同龄人相比,波斯尼亚男性房颤发病率较高[HR(95%CI)]为1.74(1.56 - 1.94),拉脱维亚男性为1.29(1.09 - 1.54),伊拉克女性为1.96(1.67 - 2.31),波斯尼亚女性为1.88(1.61 - 1.94),芬兰女性为1.14(1.11 - 1.17),爱沙尼亚女性为1.14(1.05 - 1.24),德国女性为1.08(1.03 - 1.14)。冰岛、南欧(特别是希腊、意大利和西班牙)、拉丁美洲(特别是智利)、非洲、亚洲(包括伊拉克、土耳其、黎巴嫩和伊朗)的男性房颤发病率较低(HRs≤0.60),北欧国家(芬兰除外)、南欧、西欧(德国除外)、非洲、北美、拉丁美洲、伊朗、黎巴嫩和其他亚洲国家(土耳其和伊拉克除外)的女性房颤发病率较低。总之,我们观察到移民群体与瑞典出生人群的房颤发病率存在显著差异。提高对某些移民群体房颤发病风险增加的认识,可能有助于及时诊断、治疗和预防其致残性并发症,如中风。