Lurati Ann R
1 California State University, Monterey Bay.
Workplace Health Saf. 2017 Dec;65(12):568-571. doi: 10.1177/2165079917719467. Epub 2017 Jul 13.
An employee undergoing cancer treatment was prescribed metformin, a medication used in the treatment of type 2 diabetes and currently used as adjunct therapy for cancer. Metformin's anti-inflammatory properties inhibit tumor growth. It is speculated that cancer cells develop a metabolism that enhances aerobic glycolysis, which promotes cell growth and increases the need for glucose. Metformin decreases insulin in the blood, which decreases the amount of glucose available to cancer cells, thus starving the cells of nutrition, resulting in cell death. This case study explores the role of metformin in cancer treatment, with implications for occupational health nurses.
一名正在接受癌症治疗的员工被开了二甲双胍，这是一种用于治疗2型糖尿病的药物，目前也用作癌症的辅助治疗药物。二甲双胍的抗炎特性可抑制肿瘤生长。据推测，癌细胞会形成一种增强有氧糖酵解的代谢方式，这会促进细胞生长并增加对葡萄糖的需求。二甲双胍可降低血液中的胰岛素水平，从而减少癌细胞可获得的葡萄糖量，进而使癌细胞缺乏营养，导致细胞死亡。本案例研究探讨了二甲双胍在癌症治疗中的作用，对职业健康护士具有启示意义。
