Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
Sci Rep. 2017 Jul 13;7:44954. doi: 10.1038/srep44954.
To investigate the relationship between Helicobacter pylori (Hp) infection and the long-term outcome in acute coronary syndrome (ACS) patients with drug-eluting stent (DES) implantation and so as to explore the significance of Hp eradication therapy in preventing major adverse cardiac events (MACE) and upper gastrointestinal bleeding (UGIB). 539 ACS patients with DES implantation from January 1, 2010 to December 31, 2012 were analyzed. All the patients were divided into two groups according to the result of C urea breath test. 253 patients with Hp infection were put into group A (Hp), and 286 cases without Hp infection were put into group B (Hp). Demographic data was collected and all patients went through biochemical indicators and other routine blood examinations. We explored the correlations of Hp infection with MACE and UGIB after 3 to 5 years of follow-up using survival analysis. Survival analysis showed that Hp infection was a predictor of MACE and UGI. Sub-group analysis showed that patients with Hp eradication therapy had no relationship with MACE but had a lower rate of UGIB than those without Hp eradication therapy.
探讨经皮冠状动脉介入治疗（PCI）术后患者幽门螺杆菌（Hp）感染与长期预后的关系，以及 Hp 根除治疗对预防主要不良心脏事件（MACE）和上消化道出血（UGIB）的意义。
回顾性分析 2010 年 1 月 1 日至 2012 年 12 月 31 日期间因急性冠状动脉综合征（ACS）接受经皮冠状动脉介入治疗（PCI）并植入药物洗脱支架（DES）的 539 例 ACS 患者。所有患者均根据 C 尿素呼气试验结果分为两组。253 例 Hp 感染患者纳入 Hp 阳性（Hp）组，286 例 Hp 阴性患者纳入 Hp 阴性（Hp）组。收集患者的人口统计学数据，并进行生化指标和其他常规血液检查。采用生存分析探讨 Hp 感染与 3-5 年后 MACE 和 UGIB 的相关性。
生存分析显示，Hp 感染是 MACE 和 UGIB 的预测因素。亚组分析显示，Hp 根除治疗与 MACE 无关，但与未行 Hp 根除治疗的患者相比，UGIB 发生率较低。
对于接受 PCI 治疗的 ACS 患者，Hp 感染与 MACE 和 UGIB 的发生密切相关，Hp 根除治疗可能有助于预防 UGIB，但对 MACE 无明显影响。
