幽门螺杆菌的毒力因子：综述
Virulence Factors of Helicobacter pylori: A Review.
作者信息
Roesler Bruna M, Rabelo-Gonçalves Elizabeth M A, Zeitune José M R
机构信息
Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo, Brazil. ; Center of Diagnosis of Digestive Diseases, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo, Brazil.
出版信息
Clin Med Insights Gastroenterol. 2014 Mar 27;7:9-17. doi: 10.4137/CGast.S13760. eCollection 2014.
Abstract
Helicobacter pylori is a spiral-shaped Gram-negative bacterium that colonizes the human stomach and can establish a long-term infection of the gastric mucosa, a condition that affects the relative risk of developing various clinical disorders of the upper gastrointestinal tract, such as chronic gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma. H. pylori presents a high-level of genetic diversity, which can be an important factor in its adaptation to the host stomach and also for the clinical outcome of infection. There are important H. pylori virulence factors that, along with host characteristics and the external environment, have been associated with the different occurrences of diseases. This review is aimed to analyzing and summarizing the main of them and possible associations with the clinical outcome.
摘要
幽门螺杆菌是一种螺旋形革兰氏阴性菌，可在人类胃部定植，并能在胃黏膜建立长期感染，这种情况会影响上消化道发生各种临床疾病的相对风险，如慢性胃炎、消化性溃疡病、黏膜相关淋巴组织（MALT）淋巴瘤和胃腺癌。幽门螺杆菌具有高度的遗传多样性，这可能是其适应宿主胃部以及感染临床结果的一个重要因素。存在一些重要的幽门螺杆菌毒力因子，它们与宿主特征和外部环境一起，与疾病的不同发生情况相关。本综述旨在分析和总结其中的主要因素以及与临床结果的可能关联。
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