Lancet. 1986 Apr 19;1(8486):869-72.
In a randomised controlled evaluation of multifactorial prevention of coronary heart disease (CHD) among 60 881 men employed in 80 factories in Belgium, Italy, Poland, and the UK intervention was associated with reductions of 10.2% in total CHD, 6.9% in fatal CHD, 14.8% in non-fatal myocardial infarction, and 5.3% in total deaths, with a neutral result for non-CHD deaths. Benefit was significantly related to the extent of risk factor change. The observed reduction in total CHD was 62% of that predicted by means of a multiple logistic function summary of risk factor changes. Advice on risk factor reduction in middle-aged men is effective to the extent that it is accepted and it appears to be safe.
在比利时、意大利、波兰和英国80家工厂工作的60881名男性中进行的一项多因素预防冠心病（CHD）的随机对照评估中，干预措施使总冠心病发病率降低了10.2%，致命性冠心病降低了6.9%，非致命性心肌梗死降低了14.8%，总死亡人数降低了5.3%，对非冠心病死亡则无影响。获益与危险因素变化程度显著相关。观察到的总冠心病发病率下降幅度是通过危险因素变化的多重逻辑函数汇总预测值的62%。针对中年男性降低危险因素的建议，在被接受的程度上是有效的，而且似乎是安全的。
