Dramaix M, Kornitzer M, De Backer G, Thilly C, Kittel F, Graffar M
Rev Epidemiol Sante Publique. 1981;29(3):289-303.
The Belgian Heart Disease Prevention Project is a controlled multifactorial preventive trial. It is basal on the well-documented epidemiologic notion of major coronary risk-factors: hypercholesterolemia, hypertension, smoking and obesity. This Project has been executed in industries, in males aged 40-59 yrs at the base-line screening. It is part of the WHO European Collaborative Trial including the United-Kingdom, Italy, Poland and Spain. This trial should verify a double work-hypothesis: 1 degree it is possible to modify significantly the coronary risk profile in middle-aged males through a comprehensive intervention program, 2 degrees this modification should, in turn, significantly reduce total mortality as compared to a control group. The authors discuss the pros and cons of a preventive trial in industry and review the numerous problems raised by the difficulties in modifying well-established life-styles as well as those related to the follow-up morbidity and mortality. Final screening took place in 1979-80 and results regarding incidence should be available by 1981.
比利时心脏病预防项目是一项对照多因素预防试验。它基于有充分文献记载的主要冠心病危险因素的流行病学概念：高胆固醇血症、高血压、吸烟和肥胖。该项目已在各行业针对基线筛查时年龄在40至59岁的男性开展。它是世界卫生组织欧洲协作试验的一部分，该试验包括英国、意大利、波兰和西班牙。该试验应验证一个双重工作假设：其一，通过全面的干预计划有可能显著改变中年男性的冠心病风险状况；其二，与对照组相比，这种改变应能显著降低总死亡率。作者讨论了在行业中进行预防试验的利弊，并回顾了因难以改变既定生活方式以及与随访发病率和死亡率相关的问题而引发的诸多问题。最终筛查在1979 - 1980年进行，关于发病率的结果应在1981年可得。
