The Key Laboratory of Stem Cell Biology and Neurogenomic Laboratory, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Clinical Research Center on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116011, China.
Brain Pathol. 2018 Jan;28(1):3-13. doi: 10.1111/bpa.12545. Epub 2017 Aug 6.
The most prevalent pathological features of many neurodegenerative diseases are the aggregation of misfolded proteins and the loss of certain neuronal populations. Autophagy, as major intracellular machinery for degrading aggregated proteins and damaged organelles, has been reported to be involved in the occurrence of pathological changes in many neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis. In this review, we summarize most recent research progress in this topic and provide a new perspective regarding autophagy regulation on the pathogenesis of neurodegenerative diseases. Finally, we discuss the signaling molecules in autophagy-related pathways as therapeutic targets for the treatment of these diseases.
许多神经退行性疾病最常见的病理特征是错误折叠的蛋白质聚集和某些神经元群体的丧失。自噬作为降解聚集蛋白质和受损细胞器的主要细胞内机制,据报道参与了许多神经退行性疾病的病理变化,包括阿尔茨海默病、帕金森病、亨廷顿病和肌萎缩侧索硬化症。在这篇综述中,我们总结了这一主题的最新研究进展,并提供了自噬调节在神经退行性疾病发病机制中的新视角。最后,我们讨论了自噬相关途径中的信号分子作为治疗这些疾病的治疗靶点。